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Keywords
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Poly(ethylene glycol)-bound sulfonic acid (PEG-SO3H), Bis(indolyl)methane, Bis(pyrazolyl)methane, 4,4´-(Arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol), Polymeric catalyst
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Abstract
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In this work, a green, simple and highly efficient procedure for the synthesis of bis(indolyl)methanes and 4,4′- (arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s [as an important class of bis(pyrazolyl)methanes] is described. The condensation of indoles or 1-phenyl-3-methylpyrazol-5-one with carbonyl compounds catalyzed by poly(ethylene glycol)-bound sulfonic acid (PEG-SO3H) in water affords the title compounds in high yields and relatively short reaction times.
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