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Synthesis of spirooxindole pyrimidines catalyzed by silica-bonded N-propyltriethylenetetramine as a recyclable solid base catalyst in aqueous medium
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Silica-bonded N-propyltriethylenetetramine was used as a heterogeneous solid base catalyst for the synthesis of spirooxindole pyrimidines by a one-pot condensation reaction of isatin, activated methylene reagent, and barbituric acid or thiobarbituric acid in aqueous medium in good to high yields. Catalyst could be recycled for several times without any additional treatment.
Researchers Khodabakhsh Niknam (First researcher) ,