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Title
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Solvent-free, one-pot, four-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones using sulfuric acid-modied PEG-6000 as a green recyclable and biodegradable polymeric catalyst
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Abstract
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A green practical method for the ef?cient synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)triones
using sulfuric acid-modi?ed polyethylene glycol-6000 (PEG-OSO
3
H) as an eco-friendly polymeric
catalyst from the four-component condensation reaction of phthalic anhydride, hydrazinium hydroxide,
1,3-cyclohexanedione or 5,5-dimethyl 1,3-cyclohexanedione (dimedone) and aromatic aldehydes under
solvent-free conditions at 80
C is described. This approach allowed the environmental impact factor
(E-factor) to be minimized.
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