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Title
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Synthesis of 2,3,4,5tetrasubstituted pyrroles and 1,4dihydrotetraarylpyrazines using acidic alumina as a heterogeneous catalyst
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Abstract
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Some new 2,3,4,5-tetrasubstituted pyrroles were synthesized via three-component condensation reaction of benzoin derivatives, 1,3-dicarbonyl compounds, and ammonium acetate using acidic Al2O3 as an efficient and reusable heterogeneous catalyst in refluxing ethanol in high yields. Also, acidic alumina was catalyzed 1,4-dihydro-tetraarylpyrazines by the condensation reaction of benzoins and ammonium acetate in refluxing ethanol in high yields. Alumina showed much the same efficiency when used in consecutive reaction runs.
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