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Synthesis of 2,3,4,5tetrasubstituted pyrroles and 1,4dihydrotetraarylpyrazines using acidic alumina as a heterogeneous catalyst
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Some new 2,3,4,5-tetrasubstituted pyrroles were synthesized via three-component condensation reaction of benzoin derivatives, 1,3-dicarbonyl compounds, and ammonium acetate using acidic Al2O3 as an efficient and reusable heterogeneous catalyst in refluxing ethanol in high yields. Also, acidic alumina was catalyzed 1,4-dihydro-tetraarylpyrazines by the condensation reaction of benzoins and ammonium acetate in refluxing ethanol in high yields. Alumina showed much the same efficiency when used in consecutive reaction runs.
Researchers Khodabakhsh Niknam (First researcher) ,