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Synthesis of 2-Amino-3,5-dicarbonitrile-6-thiopyridines Using Silica-bonded N-Propyldiethylenetriamine as a Heterogeneous Solid Base Catalyst
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Silica-bonded N-propyldiethylenetriamine (7) is employed as a recyclable heterogeneous solid base catalyst for the synthesis of 2amino-3,5-dicarbonitrile-6-thiopyridines through pseudo four-component condensation reaction between aromatic aldehydes, malononitrile, and 2-amino-thiophenol in refluxing ethanol. Silica-bonded N-propyldiethylenetriamine showed much the same efficiency when used in consecutive reaction runs.
Researchers Khodabakhsh Niknam (First researcher) ,