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Abstract
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Objectives: The Matrix Model is used for MA dependence in methadone services in Iran,
the most populated Persian Gulf country. However, there are no studies of the efficacy of the
Matrix Model for MA dependence while in treatment. The present study reports on the efficacy
of sixteen weeks of the Matrix Model for MA abstinence and general health.
Methods: There were MA-dependent male (n=30) and female (n=30) patients in the study
sites whom received the Matrix Model. The sites included three large methadone clinics in
Tehran, Iran during 2015. The Persian versions of the Time Line Follow Back (TLFB) and the
General Health Questionnaire-28 (GHQ-28) were completed by each participant at baseline
and treatment weeks of four, ten and sixteen. Abstinence from MA was confirmed on the
TLFB and with doing urinalyses at the same time.
Results: All subjects were daily MA users on the TLFB at baseline. General health was poor
among all subjects at baseline. There was no reported subject attrition at baseline. But, ten
subjects left the Matrix treatment before the end of week nine and 21 subjects left the Matrix
treatment before the end of week 13. At week 4, only 20% of the subjects were abstinent from
MA. At week ten, 35% of the subjects were abstinent from MA while at week 16, 65% of the
subjects were abstinent from MA. The Matrix Model led to an increased rate of abstinence
from MA (P<0.001) at week 16. Those who completed the treatment were more likely to report
improved general health (P<0.05) than those who did not at week 16.
Discussion: The study indicated that the Matrix Model significantly increased the rate of
abstinence from MA. But, at week sixteen, subject attrition was high. This issue demands
further research.
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