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Abstract
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An efficient, one-pot, two-step, four-component reaction for the synthesis of spiroindoloquinazoline
derivatives in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) is described. The syntheses are
achieved by the condensation reaction of isatin derivatives, isatoic anhydride, malononitrile and carbonyl
compounds under reflux in acetonitrile. Several of the resulting compounds showed moderate activity as
phospholipase A2 inhibitors.
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