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Title
Single-cell Transcriptional Changes in Neurodegenerative Diseases
Type Article
Keywords
single-cell RNA sequencing, neurodegenerative disease, Alzheimer’s, Parkinson, Huntington, multiple sclerosis
Abstract
In recent decades, our understanding of the molecular changes involved in neurodegenerative diseases has been transformed. Single-cell RNA sequencing and single-nucleus RNA sequencing technologies have been applied to provide cellular and molecular details of the brain at the single-cell level. This has expanded our knowledge of the central nervous system and provided insights into the molecular vulnerability of brain cell types and underlying mechanisms in neurodegenerative diseases. In this review, we highlight the recent advances and findings related to neurodegenerative diseases using these cutting-edge technologies.
Researchers Amirhossein Ahmadi (First researcher) , Juan D. Gispert (Second researcher) , Arcadi Navarro (Third researcher) , Natalia Vilor-Tejedor (Fourth researcher) , Iman Sadeghi (Fifth researcher)