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Abstract
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A desirable alternative to organic solvents, very cheap, nontoxic
and biodegradable deep eutectic solvent (DES) based on
choline chloride and urea was introduced for 2,4,6-trichloro
triazine mediated amide bond formation between carboxylic
acids and amines at room temperature. Sub-stoichiometric
amount of TCT was used as a cheap and readily available C-O
activating reagent. Various derivatives of amines were coupled
with carboxylic acids, via triacylated triazine intermediate,
resulting the reaction of acids with TCT, and the corresponding
amides were obtained in moderate to good yields.
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