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Abstract
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Xanthene derivatives are well known for their effective biological activities. In search of effective antibacterial
agents, the spiro[indoline3,9-xanthene]-trione (A) and hydroxy-spiro[indoline-3,9-xanthene]-trione (B), were
synthesized and tested for in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli.
Furthermore, the synthesized compounds were tested in vitro and in silico for their anticholinesterase activities.
The anticholinesterase activities for six substitutes of the hydroxy derivative (B1-B6) were also studied through
the molecular docking. All concentrations of compounds presented a dose-dependent antibacterial activity. The
docking results showed that all compounds are more constant than the galantamine. Amongst, compound B1
exhibited the minimum binding energy in both AChE and BChE enzymes. Results indicate the importance of
xanthene derivatives as potential antibacterial and anticholinesterases agents.
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