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Abstract
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Aim: Cu2O nanoparticles were synthesized using an extract from S. latifolium algae (SLCu2O
NPs). Their effect on PANC-1 cells and the expression of two drug resistance-related lncRNAs
were evaluated in comparison with Arsenic trioxide. Materials & methods: SLCu2O NPs were
characterized using XRD, SEM, and TEM microscopies. The effects of SLCu2O NPs on cell cytotoxicity,
cell cycle, and apoptosis, and expression of two drug resistance-related lncRNAs were examined
using MTT assay, flow cytometry, and real-time PCR,respectively. Results: SLCu2ONPs demonstrated
anti-cancer properties against PANC-1 cells comparable to Arsenic trioxide, and the expression of
lncRNAs increased upon treatment with them. Conclusion: SLCu2O NPs demonstrate anti-cancer
properties against PANC-1 cells; however, using gene silencing strategies along with SLCu2O NPs is
suggested.
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