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Title
Advancements in nanoparticle-based therapies for multidrug-resistant candidiasis infections: a comprehensive review
Type Article
Keywords
nanoparticle-based therapies, Candida auris, multidrug-resistant, antifungal agents, drug resistance
Abstract
Candida auris, a rapidly emerging multidrug-resistant fungal pathogen, poses a global health threat, with cases reported in over 47 countries. Conventional detection methods struggle, and the increasing resistance of C. auris to antifungal agents has limited treatment options. Nanoparticle-based therapies, utilizing materials like silver, carbon, zinc oxide, titanium dioxide, polymer, and gold, show promise in effectively treating cutaneous candidiasis. This review explores recent advancements in nanoparticle-based therapies, emphasizing their potential to revolutionize antifungal therapy, particularly in combating C. auris infections. The discussion delves into mechanisms of action, combinations of nanomaterials, and their application against multidrug-resistant fungal pathogens, offering exciting prospects for improved clinical outcomes and reduced mortality rates. The aim is to inspire further research, ushering in a new era in the fight against multidrug-resistant fungal infections, paving the way for more effective and targeted therapeutic interventions.
Researchers Alireza Izadi (First researcher) , Fatemeh Paknia (Second researcher) , Maryam Roostaee (Third researcher) , Seyed Amin Ayatollahi Mousavi (Fourth researcher) , Mahmood Barani (Fifth researcher)