|
Abstract
|
The skin prevents infection and contamination entering the body, and wound dressings are one of the most
serious tools in wound healing. In the present work, the biocompatibility and swelling tendency of nanofibers
increased by adding alginates to a polymer solution is investigated. Glutaraldehyde was used in different
methods to strengthen nanofibers, and it was found that a better cross-link was made from the combination of
glutaraldehyde with the polymer solution before electrospinning. As the use of drug accelerates the healing
process, dexpanthenol was added to the polymeric composition of polyvinyl alcohol (PVA) and sodium alginate
(SA) using a blending method. The resulting composition was then used as the core of the nanofibers, and drug
release was controlled by different shells. The results showed that the presence of chitosan 1% (w/v) in the shell
side of nanofibers helped better control the drug release. Also, the drug release from dexpanthenol-loaded
wound dressing followed the Fickian diffusion mechanism with the Korsmeyer-Peppas model. MTT analysis and
cell culture indicated that dexpanthenol-loaded PVA/SA/Triton-Chitosan nanofibers not only were nontoxic to
the fibroblast cells but also appropriately affected the cellular attachment and morphology. It was revealed that
PVA/SA/Triton-Chitosan nanofibers could be used for tissue engineering applications.
|