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Keywords
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Michael addition, Amide, α,β-Unsaturated ester, Microwave, Protected β-amino acid
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Abstract
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A very simple and efficient solvent-free method for the preparation of N-benzoylated β-amino esters (protected β-amino acids) via the microwave-assisted Michael addition of aromatic amides to α,β-unsaturated esters in the presence of Cs2CO3 and tetrabutylammonium bromide (TBAB) is described. The advantages of this method are efficiency, high yields and short reaction times.
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