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Title
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N,N,N',N'-Tetramethyl-N,N'-bis(sulfo)ethane-1,2-Diaminium Mesylate as a Highly Effective and Dualfunctional Catalyst for the Synthesis of 1-Thioamidoalkyl-2-naphthols
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Keywords
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N,N,N',N'-Tetramethyl-N,N'-bis(sulfo)ethane-1,2-diaminium mesylate ([TMBSED][Oms]2); Thioacetamide; 1-Thioamidoalkyl-2-naphthol; Multi-component reaction; Dicationic ionic liquid; Dual-functional catalyst
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Abstract
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N,N,N',N'-tetramethyl-N,N'-bis(sulfo)ethane-1,2-diaminium mesylate ([TMBSED][Oms]2) is used as a highly efficient and dual-functional catalyst for the one-pot multi-component condensation of 2-naphthol with arylaldehydes and thioacetamide under green, mild (70 °C), and solvent-free conditions. In this reaction, 1-thioamidoalkyl-2-naphthols are produced in high to excellent yields and in relatively short reaction times. In this reaction, products are identified by analysis of its 1H NMR, 13C NMR, and FT-IR data. Moreover, a plausible mechanism based on dual-functionality of the catalyst was proposed.
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