Title Practical synthesis of some novel unsymmetrical 1,3-dialkyl pyrimidine derivatives at room temperature Type Article Keywords 1,3-Dialkylpyrimidine, nucleobase, N3-alkylation, alkyl halide Abstract The efficient synthesis of some novel unsymmetrical 1,3-dialkylpyrimidines is described. N3-Alkylation of N1-substituted pyrimidine derivatives with various functionalized alkyl halides in the presence of catalytic amount of tetrabutylammonium bromide (TBAB) and Cs2CO3 in MeCN affords the title compounds. The reactions proceed at room temperature and the products are obtained in good to excellent yields. Researchers Ali Khalafi-Nezhad (First researcher) , Abdolkarim Zare (Second researcher) , Abolfath Parhami (Third researcher) , Mohammad Navid Soltani Rad (Fourth researcher)