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Keywords
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Isatins, 2-Aminonaphthalene-1,4-dione, Pyrazolone, Spiro compounds, Chromeno-oxindoles
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Abstract
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This study describes the design and synthesis of novel hybrid molecular architectures based on the
privileged indolin-2-one (oxindole) scaffold. The research leverages a multi-component reaction
strategy, employing isatins, 2-amino-1,4-naphthoquinone, and 5-methyl-2-phenylpyrazolone as
key building blocks. The solvent regulated the pathway to the aforementioned chemicals. The later
compounds were produced in an acetic acid solvent under reflux conditions, whereas the former
compounds were made in an ethanol solvent. Nineteen novel oxindole derivatives were synthesized
in high yields, and the structures were undoubtedly identified using their NMR data as well as X-ray
analysis.
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