February 29, 2024
Abdosaleh Zar

Abdosaleh Zar

Academic Rank: Associate professor
Degree: Ph.D in exercise physiology
Phone: 09387228086
Faculty: Faculty of Humanities


Title The effect of 4-week endurance training on serum levels of irisin and betatrophin in streptozotocin- induced diabetic rats
Type Article
Irisin, Betatrophin, Insulin resistance, Beta-cell functionendurance, training
DOI https://doi.org/10.1080/13813455.2020.1849310
Researchers Hamid Reza Sadeghipour (First researcher) , Golan Yeganeh (Second researcher) , Abdosaleh Zar (Third researcher) , Marco Bernardi (Not in first six researchers)


Betatrophin known as pancreatic β-cell proliferation marker is secreted as a result of the muscle irisin’s expression induced by exercise. The present study aimed to investigate the effect of endurance training on serum levels of irisin and betatrophin in diabetic rats. Twenty-four Wistar rats were randomly divided into three groups of (1) healthy control group (H-CG), (2) diabetic control group (D-CG), and diabetic group submitted to endurance training (D-ETG). The D-ETG performed endurance exercise (4 week/5 days) on the rodent treadmill. For data analysis we used one-way ANOVA, Scheffe test and Pearson correlation coefficient. Irisin (p = .04) and betatrophin (p = .005) levels were significantly decreased in the D-CG. Endurance exercise only increased serum levels of irisin significantly (p = .03). There was a significant correlation was shown between serum betatrophin and beta-cell function (p = .03). It appears that a specific exercise training can increase irisin hormone, with possible impact on betatrophin expression in diabetic individuals.