There are many constraints of space, light and availability of fruits to harvest in tomatoes greenhouse. Therefore, two experiments were carried out to determine the effect of shoot pruning and flower thinning on quality and quantity of fruits of semi-determinate tomato in a greenhouse of the Faculty of Agriculture and Natural Resources, Persian Gulf University of Bushehr. Experimental design was randomized complete block designs in which the effect of shoot pruning (single branch pruning, double branch pruning, pyramidal pruning and control) or flower thinning (Cluster with 4 and 5 remained flowers and control) were studied separately. Results showed that, leaf area and plants yield were higher in treatments which were pruned than control. Yields from pyramidal pruning and cluster thinning with 5 remaining flowers were significantly higher than other treatments. On the other hand, qualitative study identified that pyramidal pruning increases vitamin C in fruits, but had no significant effect on total soluble solids.