Heat transfer processes are widely used in many industrial applications such as chemical, gas, oil or food industries and many studies have been done in recent years. For this purpose, various methods for increasing heat transfer have been proposed, among which the production of vortices in the fluid flow has been the most successful in attracting researchers. In general, two methods are used to produce vortex: active and passive methods. In passive methods, vortex is created through geometric changes or by importing internal parts without any external energy source. In active methods, the vortex is generated by applying an external source that can be mechanical or electromagnetic, so in the present study, the effect of active vibrations of a piezoelectric vortex generator on the transfer heat transfer rate in a microchannel is investigated. To generate vibration, short, continuous pulses of electrical energy are sent to a piezoelectric generator. Applying electrical voltage to the piezoelectric component causes it to expand / contract, and due to the piezoelectric component's tendency to return to its original shape and size, it begins to vibrate. The vibration of the piezoelectric component produces a vortex. These vortices disrupt the thermal boundary layer and allow the flow of cold fluid to pass along the warm walls of the microchannel. It is worth noting that the interactions of generator motion with piezoelectric and fluid field in the microchannel will lead to the formation of a fluid-structural interaction problem. Heat transfer and pressure drop are obtained in the microchannel.