Market's condition is changeable and this condition force businesses to adopt themselves with new situation, technology and value propositions. In the today competitive environment, organizations try to imitate innovation from competitors, so innovation and continuous improvement is necessary for success of organizations, therefore strategic innovation is an important issue. Strategic innovation is about creation of new markets and leaps in customer value and reshaping the existing markets to achieve value improvements for customers. On the other hand, strategic entrepreneurship results from the integration of entrepreneurship and strategic management knowledge. Objective of strategic entrepreneurship is making continuous competitive advantages that lead to wealth creation. In this paper, first we introduce the concept of strategic innovation and strategic entrepreneurship, then explain the conceptual model of strategic entrepreneurship impact on strategic innovation. Statistical society of this research, is knowledge-based companies of Science and technology park of Boushehr. According to the results obtained from testing this model, the main hypothesis of this study confirm that the result shows a positive and significant relationship between strategic entrepreneurship and strategic innovation in the organization.