Hassan Habibi

Treatment of wounds is one of the issues that mankind has been facing for years, and efforts to find compounds that heal wounds without side effects are important. Since fucoidan and phycocyanin have anti-inflammatory and antioxidant effects, in this study, fucoidan and phycocyanin and their combination were used on mouse skin wounds. For this purpose, 24 male mice (15-20 gr) were anesthetized and their backs were shaved using a razor, and they were divided into 8 groups and 3 repetitions. The first group was kept without treatment as a control, the second group was treated with tetracycline (positive control), and in the other six groups, ointments made with fucoidan and phycocyanin and a combination of both were used (two concentrations of 10 and 50 µg/ml for each combination). were used), and were treated for 21 days. According to the results of this study, the best treatment for wound healing is fucoidan with a concentration of 10 µg/ml and then the phycocyanin-fucoidan combination with a concentration of 50 µg/ml. The highest production percentage of fibroblast cells belongs to fucoidan-50 µg/ml. According to the present study, the concentration of phycocyanin and fucoidan concentration of 50 µg/ml was significantly visible in hair follicles. Based on these results, it can be predicted that phycocyanin and fucoidan are two potential compounds in wound healing