Background: Gastric cancer is a heterogeneous malignant disease associated with
environmental and genetic predisposing factors. It is the fourth leading cause of
cancer death worldwide. In this way, it is important to introduce compounds that
can inhibit the growth of gastric cancer cells. It is also very important to provide
therapeutic solutions that can deliver medicinal compounds to stomach cancer cells
in a targeted manner.
Aim: Investigating the effect of chitosan-coated magnetic nanoparticles carrying
active ingredients of chamomile extract on stomach cancer cells.
Methodology: In this research, Fe3O4 magnetic nanoparticle was synthesized by
co-precipitation method and coated with chitosan (ccmnp). The properties of the
manufactured nanoparticle were analyzed using various tools such as X-ray
diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and VSM to
measure the magnetic properties of the synthesized nanoparticle. Chamomile plant
extract was prepared in aqueous form. Then, different concentrations of the extract
were analyzed in different time intervals with a spectrophotometric device to
determine the absorption of this extract in different time intervals. Also, the release
and encapsulation of chamomile extract with magnetic nanoparticles coated with
chitosan was done (ch -ccmnp) and its results were displayed as a column chart.
After encapsulation, XRD test was used to check the crystal structure of the
prepared sample, and FT-IR analysis was used to check the correctness of the
synthesis steps. In order to investigate the morphological characteristics, including
surface morphology, shape and size of nanoparticles with high resolution and
magnification using scanning electron microscope SEM of Mahamax laboratory.
Conclusions: Magnetic nanoparticles coated with effective substances of
chamomile extract can be a suitable option for future research in the treatment of
gastric cancer by inhibiting the growth and migration of gastric cancer ce