A non-fragile integral structure is developed in the discrete-time representation to illuminate the disturbance effects in the reference regulation of the uncertain systems. Hence, to investigate the effects of the exterior signals on the efficiency, the reference regulation problem is formulated in a discrete-time system. A controller method is addressed relying on linear matrix inequality. Then, in the worst cases, finding the controller’s parameters is transformed into a minimization issue. By such an optimization, the coefficients of the compensator would be estimated. Some examples are supplied to manifest the efficiencies of the presented integral tactic over similar approaches.