مشخصات پژوهش

خانه /Bayesian alignment of ...
عنوان
Bayesian alignment of proteins via Delaunay tetrahedralization
نوع پژوهش مقالات در نشریات
کلیدواژه‌ها
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چکیده
An active area of research in bioinformatics is finding structural similarity of proteins by alignment. Among many methods, the popular one is to find the similarity based on statistical features. This method involves gathering information from the complex biomolecule structure and obtaining the best alignment by maximizing the number of matched features. In this paper, after reviewing statistical models for match- ing the structural biomolecule, it is shown that local alignment based on the Delaunay tetrahedralization (DT) can be used for Bayesian alignment of proteins. In this method, we use DT to add a priori structural information of protein in the Bayesian methodology. We demonstrate that this method shows advantages over competing methods in achieving a global alignment of proteins, accelerating the convergence rate and improving the parameter estimates.
پژوهشگران سیدمرتضی نجیبی (نفر اول)، M.R. Faghihi (نفر دوم)، Mousa Golalizadeh (نفر سوم)، Shahriar Arab (نفر چهارم)