مشخصات پژوهش

خانه /Sub-acute toxicity of the ...
عنوان
Sub-acute toxicity of the alien Cassiopea andromeda (forsskal, 1775) jellyfish venom, in rats
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چکیده
The sub-acute toxicity of the crude tentacle-only extract from the alien Cassiopea andromeda (forsskal , 1775) jellyfish was studied in rat within 21 days after exposure. For sub-acute toxicity, changes in weights and pathological parameters were studied. The intraperi toneal LD50 value of venom was estimated 104.0 µg/kg BW in male mice. For sub-acute toxicity, 3 doses of crude venom (0.0125, 0.025 and 0.05 µg/ml/day) were administered intraperitoneally to female rats, once daily for 21 days. Increase in size and weights were observed in the spleens in all groups. The Scab-like spots were seen on skin of all the rats. Histopathological examinations of t he rat kidney, heart, liver and spleen tissues indicated that ther e were different demonstrable abnormalities and alt erations in the microscopic examinations in comparison to their control groups, especially at a higher dose of 0.05 µg /ml/day.
پژوهشگران غلامحسین محبی (نفر اول)، پرویز فرزادی نیا (نفر دوم)، حسین وطن پور (نفر سوم)، آرمان هاشمی (نفر چهارم)، امیر وزیری زاده (نفر پنجم)، صمد اکبرزاده (نفر ششم به بعد)، رهرا خزاعی (نفر ششم به بعد)، ایرج نبی پور (نفر ششم به بعد)، محمدرضا میرشمسی (نفر ششم به بعد)