مشخصات پژوهش

خانه /Green synthesis of novel ...
عنوان
Green synthesis of novel spiro-indenoquinoxaline derivatives and their cholinesterases inhibition activity
نوع پژوهش مقالات در نشریات
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چکیده
A convenient synthesis of substituted spiroindenoquinoxalines at mild and green conditions was developed. Multicomponent reaction of substituted phenylene diamines, ninhydrin, malononitrile and N,N’-substituted-2-nitroethene-1,1-diamines produced the target compounds. Twelve new spiroindenoquinoxalines were obtained, and their ability in inhibition of acetyl and butyrylcholinesterases were investigated both in-vitro and in-silico. All compounds showed moderate level activity against both acetyl and butyrylcholinesterases.
پژوهشگران عمار مریم آبادی (نفر اول)، علیرضا حسنی نژاد (نفر دوم)، نجمه نوروزی (نفر سوم)، غلامحسین محبی (نفر چهارم)