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Abstract
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Recently, with increased longevity and extensive media attention on healthcare matters, there is a growing consciousness among the population regarding the potential advantages of nutritional assistance in managing and preventing diseases. Polyphenols are secondary metabolites of plants that are considered highly indispensable functional foods as well as nutraceuticals. Ulcerative colitis is an intestinal inflammatory disorder, whose foremost therapeutic strategy is epitomized by synthetic anti-inflammatory medicines. Nevertheless, they are frequently accompanied by many complications that brought the interest of the scientists towards natural products. In this context, several studies asserted the anti-inflammatory effects of polyphenols such as anthocyanins, epigallocatechin gallate (EGCG), catechins, tannic acid (TA), resveratrol, and proanthocyanidins (PAC) by inhibiting the levels proinflammatory mediators and stimulated the expression of Nrf-2 dependent enzymes. However, the practical applications of polyphenols are constrained due to their poor bioavailability, and inefficient delivery to target organs, tissues, and cells. Therefore, the polyphenol's interactions with proteins in the form of polyphenol-protein particles provide a strategy to curtail the enzymatic hydrolysis and oxidative disintegration of polyphenols in the gastrointestinal tract (GIT) while increasing the bioactivity. The potential to prompt therapeutic efficacy could be attributed at least in part, to enhanced bioavailability in the intestines. This review aims to provide evidence favoring the nutraceutical potential of polyphenol-protein particles in ulcerative colitis (UC) and their mechanism and EGCG-keratinocyte growth factor, EGCG-ovalbumin, resveratrol-β-lactoglobulin, curcumin, and resveratrol-zein and Chinese mesona polysaccharides, and dihydrocaffeic acid modified with hyaluronic acid, EGCG, and KPV based particles were found to be promising in the alleviation of this condition. It
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