05 مهر 1400
حميدرضا صادقي پور

حمیدرضا صادقی پور

مرتبه علمی: استادیار
نشانی: دانشکده ادبیات و علوم انسانی - گروه علوم ورزشی
تحصیلات: دکترای تخصصی / تربیت بدنی و علوم ورزشی
تلفن: 09173300746
دانشکده: دانشکده ادبیات و علوم انسانی

مشخصات پژوهش

عنوان The effect of 4-week endurance training on serum levels of irisin and betatrophin in streptozotocin- induced diabetic rats
نوع پژوهش مقالات در نشریات
کلیدواژه‌ها
Irisin, Betatrophin, Insulin resistance, Beta-cell functionendurance, training
مجله ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
شناسه DOI https://doi.org/10.1080/13813455.2020.1849310
پژوهشگران حمیدرضا صادقی پور (نفر اول) ، گلان یگانه (نفر دوم) ، عبدالصالح زر (نفر سوم) ، محسن ثالثی (نفر چهارم) ، صمد اکبرزاده (نفر پنجم) ، مارکو برناردی (نفر ششم به بعد)

چکیده

Betatrophin known as pancreatic β-cell proliferation marker is secreted as a result of the muscle irisin’s expression induced by exercise. The present study aimed to investigate the effect of endurance training on serum levels of irisin and betatrophin in diabetic rats. Twenty-four Wistar rats were randomly divided into three groups of (1) healthy control group (H-CG), (2) diabetic control group (D-CG), and diabetic group submitted to endurance training (D-ETG). The D-ETG performed endurance exercise (4 week/5 days) on the rodent treadmill. For data analysis we used one-way ANOVA, Scheffe test and Pearson correlation coefficient. Irisin (p = .04) and betatrophin (p = .005) levels were significantly decreased in the D-CG. Endurance exercise only increased serum levels of irisin significantly (p = .03). There was a significant correlation was shown between serum betatrophin and beta-cell function (p = .03). It appears that a specific exercise training can increase irisin hormone, with possible impact on betatrophin expression in diabetic individuals.