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Title
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Self-catalyzed, reaction of benzyl halides, Na2S2O3,
and amines: a one-pot, simple, and efficient route to
thiobenzamides
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Abstract
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A new efficient, one-pot method to get thiobenzamide compounds
from benzyl halides, amines, and Na2S2O3 is reported. A benzylic
halide is treated with Na2S2O3 in DMSO until the halide is completely
consumed. Next, the reaction is continued by adding a primary or
secondary amine to the reaction mixture to synthesize thiobenzamides
simply. This procedure does not require a special catalyst or
any additive to afford thiobenzamides in good to excellent yields.
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