مشخصات پژوهش

خانه /Nanosuspensions in ...
عنوان
Nanosuspensions in ophthalmology: Overcoming challenges and enhancing drug delivery for eye diseases
نوع پژوهش مقالات در نشریات
کلیدواژه‌ها
Ophthalmic drug delivery Nanosuspensions Drug absorption Ocular diseases Drug categories Drug solubility
چکیده
This review article provides a comprehensive overview of the advancements in using nanosuspensions for controlled drug delivery in ophthalmology. It highlights the significance of ophthalmic drug delivery due to the prevalence of eye diseases and delves into various aspects of this field. The article explores molecular mechanisms, drugs used, and physiological factors affecting drug absorption. It also addresses challenges in treating both anterior and posterior eye segments and investigates the role of mucus in obstructing micro- and nanosuspensions. Nanosuspensions are presented as a promising approach to enhance drug solubility and absorption, covering formulation, stability, properties, and functionalization. The review discusses the pros and cons of using nanosuspensions for ocular drug delivery and covers their structure, preparation, characterization, and applications. Several graphical representations illustrate their role in treating various eye conditions. Specific drug categories like anti-inflammatory drugs, antihistamines, glucocorticoids, and more are discussed in detail, with relevant studies. The article also addresses current challenges and future directions, emphasizing the need for improved nanosuspension stability and exploring potential technologies. Nanosuspensions have shown substantial potential in advancing ophthalmic drug delivery by enhancing solubility and absorption. This article is a valuable resource for researchers, clinicians, and pharmaceutical professionals in this field, offering insights into recent developments, challenges, and future prospects in nanosuspension use for ocular drug delivery.
پژوهشگران سونیا فتحی کارکان (نفر اول)، نسیم امیری رامشه (نفر دوم)، حسن ارکبان (نفر سوم)، فروزان نورایی نوری (نفر چهارم)، سارا سرگزی (نفر پنجم)، شکوفه میری نژاد (نفر ششم به بعد)، مریم روستایی (نفر ششم به بعد)، سامان سرگزی (نفر ششم به بعد)، محمود بارانی (نفر ششم به بعد)، سیده محلات شادمان (نفر ششم به بعد)، Raed H. Althomali (نفر ششم به بعد)، محمد م رحمان (نفر ششم به بعد)