مشخصات پژوهش

خانه /Patterns of Brain Activation ...
عنوان
Patterns of Brain Activation during Craving in Heroin Dependents Successfully Treated by Methadone Maintenance and Abstinence-Based Treatments
نوع پژوهش مقالات در نشریات
کلیدواژه‌ها
abstinence, craving, functional magnetic resonance imaging, heroin, methadone
چکیده
Objective: Abstinence-based therapy (ABT) and methadone maintenance therapy (MMT) are common methods of treatment in heroin dependence as both suppress subjective feeling of drug craving. However, it is not clear whether the neural basis of craving suppression is similar in both types of treatments. In this study, we compared brain activation during pictorial presentation of heroin-related cues in ABT and MMT groups to understand the neural basis of drug craving in these groups. Methods: Three groups of subjects (successful ABT and MMT clients and healthy control) underwent functional magnetic resonance imaging, while heroin-related cues and neutral cues were presented to them. In addition, subjective cue-elicited craving has been measured using drug drive questionnaire before and after imaging. Result: Self-report of craving was not different between ABT and MMT groups before and after scanning. Anterior cingulate cortex and inferior frontal gyrus showed higher activations in ABT than in healthy control. Inferior frontal gyrus and superior temporal gyrus showed higher activity in ABT than in MMT. Lingual gyrus and cerebellum showed higher activity in MMT than in healthy control. Conclusions: Heroin avoidance may be achieved by MMT or ABT; however, the neural mechanism underlying these therapeutic methods differs
پژوهشگران حسین طباطیایی حعفری (نفر اول)، حامد اختیاری (نفر دوم)، حبیب گنج گاهی (نفر سوم)، پیمان حسنی ابهریان (نفر چهارم)، محمد علی عقابیان (نفر پنجم)، افسانه مرادی (نفر ششم به بعد)، ناهید صدیقی (نفر ششم به بعد)، مجتبی زارعی (نفر ششم به بعد)